Upregulation of STK15 in Esophageal Squamous Cell Carcinomas in a Mongolian Population

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منابع مشابه

Upregulation of STK15 in esophageal squamous cell carcinomas in a Mongolian population.

BACKGROUND The STK15 gene located on chromosome 20q13.2 encodes a centrosome-associated kinase critical for regulated chromosome segregation and cytokinesis. Recent studies have demonstrated STK15 to be significantly associated with many tumors, with aberrant expression obseved in many human malignancies. The purpose of this study was to investigate expression of STK15 in esophageal squamous ce...

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Role of Brg1 in progression of esophageal squamous cell carcinoma

Objective(s): Epigenetic regulation of gene expression can be carried out through chromatin remodeling enzymes such as SWI/SNF. Brg1 also known as SMARCA4 is a catalytic subunit of SWI/SNF, which is necessary for MMPs expression. Matrix metalloproteinases (MMPs) are known as important player enzymes during tumor progression and metastasis. Aberrant epigenetic modification of chromatin should be...

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The clinical significance of Aurora-A/STK15/BTAK expression in human esophageal squamous cell carcinoma.

PURPOSE Aurora-A/STK15/BTAK (Aurora-A) encodes a Serine/Threonine kinase associated with chromosomal distribution, and its up-regulation induces chromosomal instability thereby leading to aneuploidy and cell transformation in several types of cancer. In this study, we investigated the role of Aurora-A in human esophageal squamous cell carcinoma (ESCC). EXPERIMENTAL DESIGN The expression level...

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TP53 gene mutation profile in esophageal squamous cell carcinomas.

Esophageal squamous cell carcinoma is a form of cancer occurring most commonly in males, particularly those living in some areas of Asia, Africa, and western Europe. In some of these tumors, a sequence alteration has been identified in the coding region of the TP53 gene which is known to inactivate the tumor suppressor function of its product. Using a GC clamp (i.e., a GC rich domain) denaturin...

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ژورنال

عنوان ژورنال: Asian Pacific Journal of Cancer Prevention

سال: 2014

ISSN: 1513-7368

DOI: 10.7314/apjcp.2014.15.15.6021